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Source document· February 25, 2026

TransMedics outlines 20–25% 2026 revenue growth target while advancing OCS programs and European expansion

View original at seekingalpha.com
TransMedics outlines 20–25% 2026 revenue growth target while advancing OCS programs and European expansion Earnings Call Insights: TransMedics Group, Inc…
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  • Operating margins are expected to be up to approximately 250 basis points below 2025 full year levels in 2026, primarily reflecting the timing and scale of investments

    80% confidence
  • OCS Liver reached 36% of U.S. liver transplant volume in 2025, up from 26% in 2024

    80% confidence
  • TransMedics is just getting started and has sights focused on new peaks

    80% confidence
  • Total revenue for Q4 2025 was $160.8 million, representing approximately 32% growth year-over-year and approximately 12% sequential growth from Q3 2025

    80% confidence
  • Total revenue for Q4 2025 was $160.8 million, representing approximately 32% year-over-year growth and approximately 12% sequential growth

    80% confidence
  • OUS (outside U.S.) transplant revenue grew approximately 33% sequentially to $5 million in Q4 2025

    80% confidence
  • Gross margin for full year 2025 was 59.9%, up from 59.4% in 2024, reflecting logistics efficiencies and scale benefits

    80% confidence
  • OCS Liver reached 36% of U.S. liver transplant volume in 2025, up from 26% in 2024

    80% confidence
  • Total revenue for Q4 was approximately $161 million with U.S. transplant revenue at approximately $155 million, up 33% year-over-year and 11% sequentially

    80% confidence
  • TransMedics achieved its best operational performance to date in Q4 2025

    80% confidence
  • The makers of the styrofoam box technology are refusing to randomize their technology against TransMedics in ENHANCE Part B trial

    80% confidence
  • TransMedics achieved its best operational performance to date in Q4 2025 despite external challenges designed to distract and disrupt growth

    80% confidence
  • Most lung centers were waiting to see FDA approval before launching into DENOVO program

    80% confidence
  • TransMedics is laser-focused on ensuring successful execution of these initiatives throughout 2026

    80% confidence
  • TransMedics has huge opportunities ahead but also a few challenges and moving dynamics, with guidance factoring in all factors to be realistic and enable execution

    80% confidence
  • OCS was responsible for 5,139 U.S. transplants in 2025, up from 3,735 in 2024

    80% confidence
  • Competitor in ENHANCE Part B trial (makers of styrofoam box) is refusing to randomize their technology against TransMedics

    80% confidence
  • OCS was responsible for 5,139 U.S. transplants in 2025, up from 3,735 in 2024

    80% confidence
  • Total revenue for Q4 2025 was $160.8 million, representing approximately 32% growth year-over-year and approximately 12% sequential growth from Q3 2025

    80% confidence
  • TransMedics continues to expect operating margins to approach 30% by 2028

    80% confidence
  • Liver market share gains represent pure TransMedics execution excellence

    80% confidence
  • OCS Heart comprised 18% of heart transplants in 2025, up from 17% in 2024

    80% confidence
  • TransMedics is just getting started and has sights focused on new peaks

    80% confidence
  • Operating margin expanded from 8.5% in 2024 to 18% in 2025

    80% confidence
  • Operating margin expanded from 8.5% in 2024 to 18% in 2025

    80% confidence
  • TransMedics achieved our best operational performance to date with these results achieved despite external challenges earlier in the year that were designed to distract and disrupt our sustained and transformational growth

    80% confidence
  • Operating margins expected to be up to approximately 250 basis points below 2025 full year levels in 2026, primarily reflecting timing and scale of investments

    80% confidence
  • The makers of that styrofoam box is refusing to randomize their technology to ours in ENHANCE Part B

    80% confidence
  • TransMedics delivered an operating profit of approximately $21.3 million in Q4, representing approximately 13.2% of total revenue for fourth quarter while making substantial investments to fuel growth

    80% confidence
  • By organ, liver contributed $127 million, heart $26 million and lung $2 million in Q4 2025

    80% confidence
What we know · the intelligence behind this page
Live from the substrate
What we're seeing
Q4 2026 Biopharma Catalyst Cluster: Late-Stage Readouts and Regulatory Milestones
October 2026 brings a dense run of Phase 3 wins (ALOFT-IPF, RESTORE-3), new data presentations (Roche, Bayer, Lilly, Vertex, Galderma) and regulatory steps (FDA acceptance of Roche's vamikibart BLA, Scholar Rock's EMA resubmission). The next big catalyst is the ivonescimab FDA PDUFA date on 2026-11-14. Obesity combination studies (REDEFINE 4, TOGETHER-PsO) and the 2027 Maritime-1 completion point to more catalysts ahead. QAIAx's speculative AI-linked trial claims (the QIII pilot, targeted for 2027) are an unrelated micro-cap sideshow with weak evidence, and have little in common with the large-cap pipeline news.
Our read on the data ›
Signals we're tracking
EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
Patterns we're watching ›
Where sources disagree
ING Group
Both facts record the same metric (shares_outstanding) for ING Group at the identical observation date (2025-12-31). FACT A states 2,902,437,688 shares; FACT B states 2,902 million shares (2,902,000,000). The difference is 437,688 shares (~0.015%). This is a genuine value conflict, though the discrepancy appears to result from FACT B rounding to the nearest million while FACT A provides the precise count.
We flag conflicts openly ›
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